Recombinant cytomegalovirus containing foreign gene and use thereof
AssigneeSyntro Corporation
InventorsLisa J. Hock, Mark D. Cochran, Richard D. Macdonald
Life of this patent
Estimating the term…
Abstract
The present invention provides a virus comprising a DNA sequence essential for replication of a human cytomegalovirus and at least one foreign DNA sequence adapted for expression in a host. The foreign DNA sequence may encode a human immunodeficiency virus anti-sense mRNA sequence or an antigenic polypeptide, e.g., a malarial surface antigen. Also provided are therapeutic compositions and vaccines which comprise the novel viruses of the present invention.
Claims1
A recombinant herpes virus which comprises a foreign DNA sequence inserted into the herpes virus genomic DNA, wherein the foreign DNA sequence is inserted into a non-essential region, and is capable of being expressed in a herpes virus infected host cell under the control of a human cytomegalovirus immediate early (HCMV IE) promoter.
Dependencies are inferred from the claim text.