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US 5,824,703 AGranted
Method of assisting normal breathing in a mammal having a lung disorder
AssigneeSynthetic Blood International, Inc.
InventorLeland C. Clark, Jr.
Life of this patent
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AssigneeSynthetic Blood International, Inc.
InventorLeland C. Clark, Jr.
Estimating the term…
A method of assisting a mammal having a lung disorder to breathe ambient gas normally, i.e., without the assistance of a ventilator. The method includes providing an animal having a lung disorder, such as surfactant deficiency, stiff lung, or hyperinflated lung syndrome, and instilling a minimum effective dose of a perfluorochemical liquid or emulsion through the trachea for coating the alveolar sacs of a lung of the mammal. The preferred perfluorochemicals have a very low vapor pressure to avoid inducing hyperinflated lung syndrome and are supplied in a minimum effective dosage sufficient to coat the inner lung surfaces. The perfluorochemicals are permeable to the ambient gas and reside substantially permanently within the alveolar sacs without inducing hyperinflated lung syndrome. The liquid is instilled in an amount sufficient to enable the animal to breathe the ambient gas normally with O.sub.2 /CO.sub.2 blood gas exchange. Effective coating of the lungs with a small (generally <0.1 ml/kg) dose of very low vapor pressure perfluorochemical is achieved through administration of an aqueous emulsion of the perfluorochemical or a mixture of the very low vapor pressure compound in a larger volume of a higher vapor pressure carrier perfluorochemical.
A method of assisting respiration of a mammal having a lung disorder wherein lung surfactant or lung flexibility is inadequate to allow normal respiration so that the mammal can breathe normally using ambient gas without mechanical assistance, the method comprising the step of instilling a liquid mixture through the trachea of said mammal in sufficient quantity to coat alveolar sacs of lungs of said mammal, said liquid mixture comprising a high vapor pressure perfluorocarbon with a boiling point at or below 140.degree. C. at standard atmospheric conditions, selected so that the high vapor pressure perfluorocarbon evaporates from the lungs before significantly diffusing into lung tissue and before causing any hyperinflation of the lung and a minimum effective quantity, said effective quantity being less than 0.1 ml/kg of body weight, of a low vapor pressure liquid perfluorocarbon having a boiling point of at least 150.degree. C. at standard atmospheric conditions and being permeable to ambient gas for spreading to coat inside surfaces of and to persist within said alveolar sacs without inducing hyperinflated lung syndrome, thereby enabling said mammal to breathe said ambient gas without mechanical assistance and with essentially normal O.sub.2 /CO.sub.2 blood gas exchange.
A method of assisting respiration of a mammal having a lung disorder wherein lung surfactant or lung flexibility is inadequate to allow normal respiration so that the mammal can breathe normally using ambient gas without mechanical assistance by instilling an aqueous emulsion through the trachea of said mammal in sufficient quantity to coat alveolar sacs of lungs of said mammal, said aqueous emulsion comprising:
A method of assisting respiration of a mammal having a lung disorder wherein lung surfactant or lung flexibility is inadequate to allow normal respiration so that the mammal can breathe normally using ambient gas without mechanical assistance by instilling a liquid mixture through the trachea of said mammal in sufficient quantity to coat alveolar sacs of lungs of said mammal, said liquid mixture comprising:
A method of removing an effective dose of a low vapor pressure liquid perfluorocarbon that has previously been instilled into the lungs of a mammal, the method comprising the steps of:
A method for ensuring normal respiration and ameliorating or preventing lung damage in a mammal that is in receipt of an intravascular administration of a perfluorocarbon-based blood substitute containing an emulsion of a first perfluorocarbon with a boiling point at or below 140.degree. C., the method comprising administering intratracheally to said mammal an effective dose of a second perfluorocarbon to reside in the lungs of said mammal at least until the first perfluorocarbon has dissipated from the mammal, the second fluorocarbon having a boiling point of at least 150.degree. C.
A method of assisting respiration of a mammal having a lung disorder wherein lung surfactant or lung flexibility is inadequate to allow normal respiration so that the mammal can breathe normally using ambient gas without mechanical assistance, the method comprising the step of instilling a liquid mixture through the trachea of said mammal in sufficient quantity to coat alveolar sacs of lungs of said mammal, said liquid mixture comprising perfluorotetramethylcyclohexane as a diluent and a minimum effective quantity, said effective quantity being less than 0.1 ml/kg of body weight, of a low vapor pressure liquid perfluorocarbon having a boiling point of at least 150.degree. C. at standard atmospheric conditions and being permeable to ambient gas for spreading to coat inside surfaces of and to persist within said alveolar sacs without inducing hyperinflated lung syndrome,
Dependencies are inferred from the claim text.