Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders

A compound having the structure:

• ##STR13## wherein A is selected from --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --;
• R.sub.1 is selected from hydrogen or --C(O)CH.sub.2 --B--D, wherein B is oxygen or sulfur and D is selected from (i) hydrogen, (ii) --NO and (iii) --NO.sub.2, with the provision that when B is oxygen then D is H or --NO;
• R.sub.2 and R.sub.3 are independently selected from hydrogen, hydroxyl, lower alkyl, --O(O)C--R.sub.i, or --S--R.sub.i wherein R.sub.i is hydrogen, lower alkyl or lower haloalkyl, or when taken together are:
• ##STR14## wherein R.sub.i.sup.1 and R.sub.i.sup.2 are independently selected from R.sub.i wherein R.sub.i is defined as above;
• R.sub.4 and R.sub.5 are independently selected from hydrogen or halogen;
• R.sub.6 is selected from hydrogen, --NO, --NO.sub.2 and --C(O)CH.sub.2 --B--D, wherein B is oxygen or sulfur and D is selected from hydrogen, --NO and --NO.sub.2, with the provision when R.sub.1 is hydrogen, or the D group of R.sub.1 is hydrogen or --NO, with the B group being oxygen then R.sub.6 is selected from the group consisting of --NO and --C(O)CH.sub.2 --B--D, wherein B is oxygen or sulfur and D is --NO or --NO.sub.2 ;
• or an ester or thioester of said compound.