Method of increasing survival of cultured primate embryos in medium containing exogenous gonadotrophin releasor hormone
AssigneeWisconsin Alumni Research Foundation
InventorJohn P. Hearn
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Abstract
Invitro incubation of primate embryos in the presence of gonadotrophin releasor hormone (GnRH) results in enhanced chorionic gonadotrophin production associated with increased survival and attachment of the embryos. Treatment of invitro fertilized embryos with GnRH can be used to improve implantation. Agonists of GnRH reduce attachment competence of embryos and are thereby useful as post-fertilization contraceptives.
Claims2
A method of increasing survival of fertilized primate embryos up to 12 days in vitro comprising culturing a fertilized embryo in a culture medium containing a physiologically sufficient concentration of exogenous gonadotrophin releasor hormone to increase fertilized embryo survival from the time of said embryo's suspension in culture medium up to implantation in a receptive uterus, wherein the fertilized embryo is selected from the group consisting of a morula, blastomere, and blastocyst.
Dependencies are inferred from the claim text.