Polypeptides having kinase activity, their preparation and use
AssigneeLudwig Institute for Cancer Research
InventorsIan D. Hiles, Michael J. Fry, Ritu Dhand, Michael D. Waterfield, Peter J. Parker, Masayuki Otsu, George Panayoutou, Stefano Volinia, Ivan Gout
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Abstract
This invention relates to new polypeptides which exhibit kinase activity or, more specifically, which show phosphoinositide (PI) 3-kinase activity. Such polypeptides are involved in pathways responsible for cellular growth and differentiation. An isolated polypeptide which possesses PI3-kinase activity when produced by recombinant production in insect cells is disclosed.
Claims7
Isolated, human polypeptide which has PI3 kinase activity and a molecular weight of about 110 kilodaltons as determined by SDS-PAGE.
Isolated polypeptide consisting of amino acids 19-10 of SEQ ID NO:32.
Isolated polypeptide selected from the group consisting of:
- (a) amino acids 1-128 of SEQ ID NO:
- 32;
- (b) amino acids 1-108 of SEQ ID NO:
- 32, and
- (c) amino acids 19-108 of SEQ ID NO:
- 32.
Dependencies are inferred from the claim text.