Dry reagent test strip comprising benzidine dye precursor and antipyrine compound
AssigneeMercury Diagnostics, Inc.
InventorsJohn Hedger Priest, Eric Michael Nelson
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Abstract
A dry reagent test strip for determining the concentration of an analyte in a liquid sample is described. The test strip has a matrix containing reagent detection chemistry, which includes an oxidase enzyme that can utilize the analyte as a substrate forming hydrogen peroxide, a benzidine dye precursor, a peroxidase enzyme, and an antipyrine compound. The addition of an antipyrine compound to the reagent detection chemistry provides a standard concentration graph which is substantially linear in a desired range of analyte concentration. The precision and accuracy of reading the test strip are enhanced.
Claims14
A dry reagent test strip for determining the concentration of an analyte in a liquid sample, the test strip comprising a matrix containing reagent detection chemistry, the reagent detecting chemistry comprising:
- an oxidase enzyme that utilizes the analyte as a substrate forming hydrogen peroxide;
- a benzidine dye precursor;
- a peroxidase enzyme;
- and an antipyrine compound, wherein the antipyrine compound produces a standard curve of analyte concentration versus reflectance which is substantially linear in the desired range when the analyte contacts the reagent detecting chemistry.
A dry reagent test strip for determining the concentration of glucose in a sample of whole blood, the test strip comprising a matrix containing reagent detection chemistry, the reagent detecting chemistry comprising:
- glucose oxidase, a benzidine dye precursor, peroxidase and an antipyrine compound , wherein the antipyrine compound produces a standard curve of glucose concentration versus reflectance which is substantially linear in the desired range when the glucose contacts the reagent detecting chemistry.
Dependencies are inferred from the claim text.