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US 5,824,470 AGranted
Method of preparing probes for sensing and manipulating microscopic environments and structures
AssigneeCalifornia Institute of Technology
InventorsJohn D. Baldeschwieler, David Randall Baselt, Marc A. Unger, Stephen D. O'Connor
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Abstract
Probes for sensing and manipulating microscopic environments and structures, their method of preparation and methods of use are disclosed.
Claims5
A method of preparing a probe for sensing or manipulating a microscopic environment or structure comprising the steps of:
- (a) protecting a small area at the tip of the probe, wherein said area of protection is in the range of about 10,000 .ANG..sup.2 to 3 .ANG..sup.2 ;
- (b) passivating the unprotected area of said probe tip;
- (c) deprotecting the protected area of said probe tip;
- and
- (d) functionalizing the deprotected area at the tip of said probe with a desired moiety.
2 more elements
A method of preparing a probe for sensing or manipulating a microscopic environment or structure comprising the steps of:
- (a) activating a small area at the tip of the probe towards functionalization;
- (b) functionalizing said area with a desired moiety, comprising a single, rigid macromolecule that has an outer distal diameter in the range of about 2 .ANG. to about 50 .ANG.;
- and
- (c) passivating the non-activated area of said tip (if necessary).
1 more element
A method of preparing a probe for sensing or manipulating a microscopic environment or structure comprising the steps of:
- (a) protecting a small area at the tip of the probe;
- (b) passivating the unprotected area of said probe tip;
- (c) deprotecting the protected area of said probe tip;
- and
- (d) functionalizing the deprotected area at the tip of said probe with a desired moiety comprising a single, rigid macromolecule that has an outer distal diameter in the range of about 2 .ANG. to about 50 .ANG..
2 more elements
Dependencies are inferred from the claim text.