Treatment of tumors with monoclonal antibodies against oncogene antigens
AssigneeThe Trustees of the University of Pennsylvania
InventorsMark I. Greene, Jeffrey A. Drebin
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Abstract
A method of treating certain mammalian tumors with monoclonal antibodies is provided. Monoclonal antibodies specific to distinct epitopes of p185, the translation production of the neu oncongene, are provided, and these are then contacted with the tumor antigen under conditions which allow binding of the antibodies to a degree sufficient to inhibit tumor growth. The monoclonal antibodies act synergistically thus enhancing their anti-tumorigenic effect upon the tumor. An injectable composition for treating certain mammalian tumors with monoclonal antibodies and methods for diagnosing mammalian cancer tumors which express the protein p185 on the surface of the cells are also disclosed.
Claims24
A method of treating mammalian cancer tumors having cells which express p185 the translation product of the neu oncogene on their surfaces, comprising the steps of:
- a) providing a first antibody specific for a first epitope on an extracellular domain of said translation product;
- b) providing a second antibody specific for a second epitope on an extracellular domain of said translation product, the combination of said first and second antibodies being selected to produce synergistic inhibition of tumor growth;
- and
- c) contacting said cells with said first and second antibodies under conditions which allow said first and second antibodies to bind to said translation product on the surfaces of said cells to a degree sufficient to inhibit the growth of the tumor.
An injectable composition for treatment of a mammalian cancer tumor having cells which express p185 the translation product of the neu oncogene on the surfaces of the cells, comprising
- a) a first antibody specific to a first epitope on an extracellular domain of said translation product;
- b) a second antibody specific to a second epitope on an extracellular domain of said translation product the combination of said first and second antibodies being selected to produce synergistic inhibition of tumor growth;
- and
- c) a pharmaceutically acceptable injection vehicle.
A method of treating mammalian cancer tumors having cells which express p185 the translation product of the neu oncogene on their surfaces, comprising the step of:
- injecting a mammal having such tumors, with an injectable composition consisting essentially of:
- a pharmaceutically acceptable injection vehicle, a first antibody specific for a first epitope on an extracellular domain of said translation product, and a second antibody specific for a second epitope on an extracellular domain of said translation product, the combination of said first and second antibodies being selected to produce synergistic inhibition of tumor growth.
An injectable composition for treatment of a mammalian cancer tumor having cells which express p185 the translation product of the neu oncogene on the surfaces of the cells, consisting essentially of
- a) a first antibody specific to a first epitope on an extracellular domain of said translation product;
- b) a second antibody specific to a second epitope on an extracellular domain of said translation product the combination of said first and second antibodies being selected to produce synergistic inhibition of tumor growth;
- and
- c) a pharmaceutically acceptable injection vehicle.
Dependencies are inferred from the claim text.