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US 5,824,307 AGranted
Human-murine chimeric antibodies against respiratory syncytial virus
AssigneeMedImmune, LLC
InventorLeslie Sid Johnson
Life of this patent
Estimating the term…
Abstract
This invention relates to a human antibody which contains the one CDR from each variable heavy and variable light chain of at least one murine monoclonal antibody, against respiratory syncytial virus which is MAb1129 and the use thereof for the prevention and/or treatment of RSV infection.
Claims30
A neutralizing antibody against RSV, comprising:
- a human constant region and a variable region, said variable region comprising heavy and light chain framework regions and heavy and light chain CDRs, at least a portion of the heavy and light chain framework regions being derived from a human antibody, said neutralizing antibody against respiratory syncytial virus binding to the same epitope as an antibody comprising three heavy chain CDRs comprising amino acids 31-37, 52-67 and 100-109 of SEQ ID NO:31, and three light-chain CDRs comprising amino acids 24-33, 51-56 and 89-96 of SEQ ID NO:34.
A neutralizing antibody against respiratory syncytial virus, comprising:
- a human constant region and a heavy and light chain variable region, said heavy and light chain variable region comprising heavy and light chain framework regions and heavy and light chain CDRs, at least a portion of the heavy and light chain framework regions being derived from a human antibody, said CDRs comprising three heavy-chain CDRs comprising amino acids 31-37, 52-67 and 100-109 of SEQ ID NO:31 and three light-chain CDRs comprising amino acids 24-33, 51-56 and 89-96 of SEQ ID NO:34.
Dependencies are inferred from the claim text.