Back to results
US 5,824,080 AGranted
Photochemistry for the preparation of biologic grafts--allografts and xenografts
AssigneeThe General Hospital Corporation
InventorGlenn M. Lamuraglia
Life of this patent
Estimating the term…
Abstract
Photodynamic therapy (PDT), a technique to produce cytotoxic free radicals, was used to prepare arterial allografts. After impregnation with the photo-sensitizer chloroaluminum sulfonated phthalocyanine, aortas of ACI rats were PDT-treated and transplanted in Lewis rats. PDT grafts were completely reendothelialized by 4 weeks.
Claims7
A method for reducing host rejection of a biologic graft, said method comprising the steps of:
- (a) contacting a tissue graft with a photosensitizing compound, and
- (b) exposing said graft to electromagnetic radiation for a predetermined time and in an amount effective to transform the photosensitizing compound into an excited state, wherein said exposure results in the activation of the photosensitizing compound to produce an activated free-radical moiety which causes the death of rejection-inducing cells of the graft.
Dependencies are inferred from the claim text.