Medical devices containing in-situ generated medical compounds

A process for impregnating a medical device comprising a water absorbable polymer material with a medical compound having water solubility less than about 0.5 g/liter comprising:

• a) contacting at least a portion of said device with a first aqueous solution containing a first water soluble ionizable compound dissolved therein such that the contacted portion of said device is infiltrated by said first aqueous solution;
• b) contacting said portion of said device with a second aqueous solution containing a second water soluble ionizable compound dissolved therein such that the contacted portion of said device is also infiltrated by said second aqueous solution;
• said water soluble compounds characterized by the fact that the ions thereof react after contact to form said medical compound having water solubility less than about 0.5 g/liter within said device,
• said water absorbable polymer material comprising ionically or covalently crosslinked hydrogel;
• and
• said medical compound being selected from the group consisting of radiopaque compounds present in said device at a level of from about 5 to about 15 wt % and antiseptic agents present in said device at a level of from about 0.01 to about 5 wt %.