Multipurpose anti-microbial silastic sheath system for the prevention of device-related infections
AssigneeBoard of Regents, The University of Texas Systems
InventorsRobert Tcholakian, Issam Raad
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Abstract
The present invention relates generally to indwelling medical devices. In particular, there is provided a device constructed from permeable or nonpermeable material having a pharmacologically active ingredient layer surrounding the device, and an outer sheath which is permeable to the pharmacologically active ingredient. This construction provides a device that allows the pharmacologically active ingredient located between the catheter tube and the outer sheath to slowly diffuse through the outer sheath and/or inner tube, thus inhibiting microbial infection on the outer surface and lumen of the catheter.
Claims34
An urethral catheter comprising:
- (i) a catheter;
- (ii) an outer sheath comprising a silicone compound concentric to and surrounding said catheter;
- and
- (iii) a pharmacologically active agent circumferentially located between said catheter and said outer sheath, wherein said pharmacologically active agent is embedded in a jacket of hydrophobic pharmacologically active agent-permeable material,
- and wherein said outer sheath is permeable to said pharmacologically active agent to allow said pharmacologically active agent to slowly diffuse through the outer sheath, and also diffuse into the lumen of the catheter.
A venous or arterial catheter comprising:
- (i) a catheter;
- (ii) an outer sheath comprising a silicone compound concentric to and surrounding said catheter;
- and
- (iii) a pharmacologically active agent circumferentially located between said catheter and said outer sheath, wherein said pharmacologically active agent is embedded in a jacket of hydrophobic pharmacologically active agent-permeable material,
- and wherein said outer sheath is permeable to said pharmacologically active agent to allow said pharmacologically active ingredient to slowly diffuse through said outer sheath.
A method of using an indwelling medical construct comprising the steps of:
- (i) providing an indwelling medical construct comprising:
- (a) a tube comprising a silicone compound and having a hollow inner lumen;
- (b) an outer sheath comprising a silicone compound concentric to and surrounding said tube;
- and
- (c) a pharmacologically active agent circumferentially located between said tube and said outer sheath, wherein said pharmacologically active agent is embedded in a jacket of hydrophobic pharmacologically active agent-permeable material,
- and wherein said outer sheath and hollow tube are permeable to said pharmacologically active agent to slowly diffuse through the outer sheath, and also diffuse into said lumen of said tube;
- and
- (ii) inserting said construct into a patient.
An indwelling medical construct comprising:
- (i) an implantable medical device or a tube;
- (ii) a sheath comprising a silicone compound surrounding part or all of said device or tube, said sheath being concentric to and surrounding said device or tube;
- and
- (iii) at least one pharmacologically active agent circumferentially located between said device or tube and said sheath, wherein said pharmacologically active agent is embedded in a jacket of hydrophobic pharmacologically active agent-permeable material,
- and wherein said sheath is permeable to said pharmacologically active agent to allow said pharmacologically active agent to slowly diffuse through said sheath.
Dependencies are inferred from the claim text.