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US 5,817,807 AGranted
Antiviral compounds
AssigneeAnorMED, Inc.
InventorsGary J. Bridger, Sreenivasan Padmanabhan, Renato T. Skerlj, Pedro E. Hernandez-Abad, Milind P. Sant
Life of this patent
Estimating the term…
Abstract
Macrocyclic compounds having 1, 4, 8, 11-tetraazacyclotetradecanyl group, show good selectivity against HIV-1 and HIV-2, in in vitro tests are disclosed.
Claims5
A macrocyclic compound of general formula I,
- V--CR.sup.1 R.sup.2 --Ar--CR.sup.3 R.sup.4 --N (R.sup.5)--(CR.sup.6 R.sup.7).sub.x --R.sup.8) (I)
- wherein V is a 1,4,8,11-tetraazacyclotetra- decanyl group;
- R.sup.1 to R.sup.7 may be the same or different and are independently selected from hydrogen or straight, branched or cyclic C.sub.1-6 alkyl;
- R.sup.8 is a pyridine, pyrimidine, pyrazine, imidazole, thiophene, thiophenyl, aminobenzyl, piperidinyl, piperazinyl group, or a mercaptan group;
- Ar is a phenylene ring optionally substituted with an electron donating or withdrawing group selected from the group consisting of alkyl, aryl, amino, alkoxy, hydroxy, halogen, carboxyl and carboxamido;
- x is 1 or 2;
- and the acid addition salts and metal complexes thereof.
4 more elements
Dependencies are inferred from the claim text.