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US 5,817,674 AGranted
Quinoline compounds
AssigneeRoussel Uclaf
InventorsFrancois Clemence, Michel Fortin, Jean-Luc Haesslein
Life of this patent
Estimating the term…
Abstract
Compounds of the formula ##STR1## in all possible racemic, enantiomeric and diastereoisomeric forms and their non-toxic, pharmaceutically acceptable salts with acids and bases having antagonistic properties for angiotensin II receptors and a process and novel intermediates for their properties.
Claims8
A compound selected from the group consisting of all possible racemic, enantiomeric and diasteroisomeric forms of a compound of the formula ##STR69## wherein R.sub.2B and R.sub.3B are individually selected from the group consisting of
- a) hydrogen, hydroxy, mercapto, cyano, nitro, alkyl of 1 to 4 carbon atoms unsubstituted or substituted by --OH,
- b) alkoxy of 1 to 4 carbon atoms unsubstituted or substituted with at least one fluorine, alkylthio of 1 to 6 carbon atoms, acyl of an organic carboxylic acid of 1 to 4 carbon atoms, amino and carbamoyl unsubstituted or substituted with a member selected from the group consisting of alkyl and alkenyl of up to 6 carbon atoms, free carboxy, salified carboxy, carboxy esterified with alkanol of 1 to 6 carbon atoms,
- A.sub.1B is nitrogen and A.sub.2B and A.sub.3B are ##STR70## and R.sub.1 is selected from the group consisting of hydrogen, hydroxyl, cyano, carboxy free, salified or esterified by alkyl of 1 to 4 carbon atoms, alkyl, alkenyl, alkoxy, acyl and alkylthio of up to 7 carbon atoms, phenyl, benzyl, phenoxy, phenylthio, all of the aliphatic or cyclic unsubstituted or substituted by a member of the group consisting of halogen, trifluoromethyl, cyano, carboxy free, salified or esterified by alkyl of 1 to 4 carbon atoms, tetrazole and isoxazole, and A.sub.4B is --C--R.sub.5B --Y, R.sub.5B is --CH.sub.2 --, and Y is biphenyl unsubstituted or substituted by a member of the group consisting of hydroxyl, halogen, alkyl and alkoxy of 1 to 4 carbon atoms, trifluoromethyl, cyano nitro, free salified or esterified carboxy tetrazole and isoxazole and their non-toxic, pharmaceutically acceptable addition salts with mineral and organic acids and mineral and organic bases.
Dependencies are inferred from the claim text.