Antidote for hirudin and synthetic thrombin inhibitors and method of use
AssigneeMax-Planck-Gesellschaft
InventorsGotz Nowak, Elke Bucha
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Abstract
The invention relates to an antidote for hirudin and synthetic thrombin inhibitors; the antidote contains a compound that splits prothrombin into meizothrombin, a prothrombin intermediate, a pharmacologically acceptable salt thereof or a mixture of these compounds, together with conventional vehicles and/or diluents. The present invention also relates to the application of a compound that splits prothrombin into meizothrombin, a prothrombin intermediate, or a pharmacologically acceptable salt thereof or a mixture of these compounds, together with conventional vehicles and/or diluents as an antidote for hirudin and synthetic thrombin inhibitors or for the preparation of an antidote for hirudin and synthetic thrombin inhibitors.
Claims12
A parenterally administrable antidotal composition for hirudin and for synthetic thrombin inhibitors, said composition containing (A) a hirudin or a synthetic thrombin inhibitor antidotal amount of a component selected from the group consisting of (1) a snake venom or a purified fraction thereof or a pharmacologically acceptable salt of said venom or fraction that splits prothrombin into meizothrombin, (2) a prothrombin intermediate or a pharmacologically acceptable salt of said prothrombin intermediate, said intermediate selected from the group consisting of meizothrombin, PIVKA prothrombin, meizothrombin-des-fragment-1 and a compound containing meizothrombin and (3) a mixture of (1) and (2), and (B) a conventional parenterally administrable vehicle.
Dependencies are inferred from the claim text.