Encapsulated and non-encapsulated nitric oxide generators used as antimicrobial agents
AssigneesThe United States as represented by the Department of Health and Human Services, EntreMed, Inc.
InventorsShawn J. Green, Larry K. Keefer
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Abstract
This invention relates to compositions capable of releasing nitric oxide and therapeutic methods of use thereof for the treatment of microorganism-related disease states. The composition comprises one or more nitric oxide generators, preferably encapsulated in vesicles, such as liposomes. The compositions are used therapeutically by administration to humans and animals via different routes for the treatment of infectious diseases caused by pathogenic microbes.
Claims26
A method of killing or inhibiting the proliferation of infectious or pathogenic microorganisms in a human or an animal, which method comprises administering to said human or animal a compound capable of releasing nitric oxide in an aqueous solution such that said infectious or pathogenic microorganisms are exposed to nitric oxide and such that the proliferation of said infectious or pathogenic microorganism is inhibited or said infectious or pathogenic microorganism is killed.
Dependencies are inferred from the claim text.