Method for the synthesis, compositions and use of 2'-deoxy-5-fluoro-3'-thiacytidine and related compounds
AssigneeEmory University
InventorsDennis C. Liotta, Raymond F. Schinazi, Woo-Baeg Choi
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Abstract
The present invention relates to a method of preparing the antiviral compounds 2'-deoxy-5-fluoro-3'thiacytidine (FTC) and various prodrug analogues of FTC from inexpensive precursors with the option of introducing functionality as needed; methods of using these compounds, particularly in the prevention and treatment of AIDS; and the compounds themselves. This synthetic route allows the stereoselective preparation of the biologically active isomer of these compounds and related compounds.
Claims2
.beta.-2'-Deoxy-5-fluoro-3'-thiacytidine.
A pharmaceutical composition comprising an effective HIV treatment amount for humans of .beta.-2'-deoxy-5-fluoro-3'-thiacytidine in a pharmaceutically acceptable carrier or diluent.
Dependencies are inferred from the claim text.