Method for delivering bioactive agents into and through the mucosally associated lymphoid tissues and controlling their release
AssigneesSouthern Research Institute, The UAB Research Foundation
InventorsThomas R. Tice, Richard M. Gilley, John H. Eldridge, Jay K. Staas
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Abstract
A method, and compositions for use therein capable, of delivering a bioactive agent to an animal entailing the steps of encapsulating effective amounts of the agent in a biocompatible excipient to form microcapsules having a size less than approximately ten micrometers and administering effective amounts of the microcapsules to the animal. A pulsatile response is obtained, as well as mucosal and systemic immunity.
Claims16
A method of delivering a bioactive agent to an animal to initiate an immune response, comprising parenterally administering an immunogenically effective amount of microcapsules to said animal, wherein said microcapsules comprise said bioactive agent encapsulated in a biocompatible excipient and wherein said microcapsules are of a size of between approximately 1 micrometer and approximately 10 micrometers.
A method of delivering a bioactive agent to an animal to initiate an immune response, comprising parenterally administering an immunogenically effective amount of microcapsules to said animal, wherein said microcapsules comprise said bioactive agent encapsulated in a biocompatible excipient and wherein said microcapsules are of a size of less than approximately 10 micrometers.
Dependencies are inferred from the claim text.