# US 5,811,609 A · Process for the preparation of a water dispersible carotenoid preparation in powder form

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- Number: US 5,811,609 A
- Document ID: US5811609A
- Status: Granted
- Kind: A
- Application number: 08/501,057
- Filed: 1995-08-30
- Granted: 1998-09-22
- Earliest claimed: 1993-02-19
- Assignees: Danochemo A/S
- Inventors: Per Vilstrup; Nina Musaeus Jensen; Sven Krag-Andersen
- Web page: https://patentgrep.com/patent/US5811609A

## CPC

- C07C 403/24: having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
- A23L 5/44: using carotenoids or xanthophylls
- A61K 9/146: {with organic macromolecular compounds}
- A61K 31/015: carbocyclic
- A61K 31/12: Ketones
- C09B 61/00: Dyes of natural origin prepared from natural sources {, e.g. vegetable sources}
- C09B 67/0095: {Process features in the making of granulates}
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C09B: ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES {, e.g. PIGMENTS}; MORDANTS; LAKES (fermentation or enzyme using processes to synthesise a desired chemical compound C12P)

## Abstract

A powdered water-dispersible carotenoid preparation in the form of discrete carotenoid microparticles is prepared by milling a carotenoid in an aqueous medium in the presence of a hydrocolloid so as to form a suspension, heating the suspension thus formed to a sufficiently high temperature to cause a total or partial melting of the carotenoid and cooling, finely dividing and drying the suspension to form a powder.

## Claims

### Claim 1

Process for the preparation of a powdered water-dispersible carotenoid preparation in the form of discrete carotenoid microparticles comprising the steps of milling a carotenoid in an aqueous medium in the presence of a hydrocolloid to form a suspension, heating the suspension formed by the milling to a temperature sufficiently high to cause a total or partial melting of the carotenoid, subsequently cooling the suspension, and finely dividing and drying the suspension to form a powder.

### Claim 2 (depends on 1)

Process according to claim 1, wherein the suspension is heated to a temperature slightly above the melting point of the carotenoid.

### Claim 3 (depends on 1)

Process according to claim 1 wherein the suspension is maintained at the high temperature for a period of from 0.05 to 200 seconds.

### Claim 4 (depends on 1)

Process according to claim 1, wherein the carotenoid is .beta.-carotene and wherein the suspension is heated to a temperature of 150.degree.-200.degree. C. for a period of from 5 to 150 seconds.

### Claim 5 (depends on 1)

Process according to claim 1, wherein the heat-treated suspension is quickly cooled to a temperature of between room temperature and 80.degree. C.

### Claim 6 (depends on 1)

Process according to claim 1, wherein the heating of the suspension is effected under a sufficiently high pressure to prevent evaporation of the liquid.

### Claim 7 (depends on 1)

Process according to claim 1, wherein the hydrocolloid used is gelatine.

### Claim 8 (depends on 1)

Process according to claim 1, including the step of adding an aqueous hydrocolloid solution to the heat-treated suspension before it is finely divided and dried.

### Claim 9 (depends on 3)

Process according to claim 3, wherein the suspension is maintained at the high temperature for 0.2 to 100 seconds.