Prophylactic and therapeutic methods for ocular degenerative diseases and inflammations and histidine compositions therefor

A method for treating ocular inflammation associated with at least one of degenerative eye conditions, chronic eye conditions, a secondary sequela of primary disease, an infectious agent, an ophthalmic procedure, and unintentional eye trauma in a mammal comprising administering to said mammal a therapeutically effective amount of D-histidine, L-histidine, racemic or non-racemic mixtures of histidine, or pharmaceutically acceptable salts thereof.

A method for enhancing wound healing following a corneal excimer laser procedure comprising administering to a patient at a time comprising at least one of before, during, and after the corneal excimer laser procedure an amount of D-histidine, L-histidine, racemic or non-racemic mixtures of histidine, or pharmaceutically acceptable salts thereof effective to prevent a regrowth of non-planar keratocytes.

A composition for administration to an eye to treat ocular inflammatory conditions, comprising a therapeutically effective amount of D-histidine, L-histidine, racemic or non-racemic mixtures of histidine, or pharmaceutically acceptable salts thereof, an ophthalomological carrier therefor, and optionally, formulation adjuvants.

An eye cosmetic composition comprising a mascara, a liquid eyeliner, or an eye creme and an antiinflammation effective amount of D-histidine, L-histidine, racemic or non-racemic mixtures of histidine, or pharmaceutically acceptable salts thereof.

A method of preventing or treating corneal haze formation in an eye of a patient to undergo or having undergone laser-assisted photoablative surgical procedure causing a removal of corneal tissue, comprising administering to said patient at a time comprising before, during, or after said photoablative procedure an amount of D-histidine, L-histidine, racemic or non-racemic mixtures of histidine, or pharmaceutically acceptable salts thereof, effective to prevent or treat corneal haze formation.