Bicyclic heterocyclic compounds
AssigneeBayer Aktiengesellschaft
InventorsRichard Connell, Siegfried Goldmann, Ulrich Muller, Stefan Lohmer, Hilmar Bischoff, Dirk Denzer, Rudi Grutzmann, Stefan Wohlfeil
Life of this patent
Estimating the term…
Abstract
The bicyclic heterocyclic compounds are prepared by reaction of correspondingly substituted carboxylic acids with amines, in particular with phenylglycinolamine. The bicyclic heterocyclic compounds according to the invention are suitable as active compounds in medicaments, in particular in medicaments having an antiatherosclerotic action.
Claims6
A bicyclic heterocyclic compound of the formula (I) ##STR258## which A represents a radical of the formula ##STR259## wherein L and M are identical or different and denote hydrogen, halogen, trifluoromethyl, carboxyl, cycloalkyl having 3 to 6 carbon atoms, hydroxyl, phenyl or straight-chain or branched alkyl, alkoxycarbonyl or alkoxy having in each case up to 6 carbon atoms,
- R.sup.5 denotes hydrogen, straight-chain or branched alkyl having up to 6 carbon atoms, benzyl or phenyl, which are optionally substituted by halogen or by straight-chain or branched alkyl having up to 6 atoms,
- D and E are identical or different and represent hydrogen, halogen, trifluoromethyl, hydroxyl or carboxyl, or represent straight-chain or branched alkyl, alkoxy or alkoxycarbonyl having in each case up to 6 carbon atoms,
- Z represents an oxygen or sulphur atom,
- R.sup. represents cycloalkyl having 3 to 10 carbon atoms, or represents straight-chain or branched alkyl having 1 to 10 carbon atoms, or represents
- phenyl, which is optionally substituted up to twice in an identical or different manner by halogen, nitro, cyano, hydroxyl or straight-chain or branched alkyl or alkoxy having in each case up to 4 carbon atoms,
- R.sup.2 represents hydrogen or straight-chain or branched alkyl having up to 3 carbon atoms,
- R.sup.3 represents hydrogen or straight-chain or branched alkyl having up to 5 carbon atoms, or represents
- cycloalkyl having 3 to 7 carbon atoms, or represents phenyl or benzyl, or represents a 5- to 7-membered aromatic heterocyclic radical having up to 3 heteroatoms selected from the group
- consisting of S, N and O, which are optionally substituted up to 3 times in an identical or different manner by halogen, nitro, phenyl, hydroxyl or by straight-chain or branched alkyl or alkoxy having up to 6 carbon atoms,
- R.sup.4 represents hydrogen, or represents a group of the formula
- --CH.sub.2 --OH or CH.sub.2 O--CO--R.sup.11,
- wherein
- R.sup.11 denotes hydrogen, straight-chain or branched alkyl having up to 8 carbon atoms or phenyl, which is optionally substituted up to 3 times in an identical or different manner by halogen, hydroxyl, cyano or straight-chain or branched alkyl or alkoxy having in each case up to 4 carbon atoms,
- or a salt thereof.
Dependencies are inferred from the claim text.