Method of modifying the surface of a medical device
AssigneeMedtronic, Inc.
InventorsMarc Hendriks, Michel Verhoeven, Linda L. Cahalan, Patrick T. Cahalan, Benedicte Fouache
Life of this patent
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Abstract
A medical device having a surface graft matrix comprising carboxyl-functional groups located on the device, the surface graft matrix comprising an outer portion; and one or more biomolecules covalently coupled to the surface graft matrix, wherein a majority of the biomolecules are located in the outer portion of the surface graft matrix. The surface graft matrix can also be loaded with a pharmaceutical agent.
Claims15
A method of modifying the surface of a medical device comprising:
- (a) forming a surface graft matrix comprising carboxyl-functional groups on the surface of a medical device;
- (b) treating the surface graft matrix with an aqueous solution having a pH that is less than the pKa of the surface graft matrix;
- and
- (c) covalently coupling one or more biomolecules to the surface graft matrix in an aqueous solution having a pH that is less than the pKa of the surface graft matrix, wherein a majority of the biomolecules are located in the outer portion of the surface graft matrix.
A method of modifying the surface of a medical device comprising:
- (a) forming a surface graft matrix comprising carboxyl-functional groups on the surface of a medical device;
- (b) treating the surface graft matrix with an aqueous solution having a pH that is less than the pKa of the surface graft matrix;
- (c) covalently coupling one or more linker molecules to the surface graft matrix in an aqueous solution having a pH that is less than the pKa of the surface graft matrix, wherein a majority of the linker molecules are located in the outer portion of the surface graft matrix;
- and
- (d) covalently coupling one or more biomolecules to the linker molecules.
A method of delivering a pharmaceutical agent comprising contacting a body with a medical device comprising a surface graft matrix comprising carboxyl-functional groups located on the device, the surface graft matrix comprising an outer portion in which a majority of one or more biomolecules are coupled, wherein the pharmaceutical agent is located within the surface graft matrix when the device is initially contacted with the body.
Dependencies are inferred from the claim text.