Controlled release matrix for pharmaceuticals
AssigneeEuro-Celtique S.A.
InventorThinnayam N. Krishnamurthy
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Abstract
A controlled release pharmaceutical composition for oral administration in humans or animals, comprising a controlled release matrix comprising a pharmaceutically acceptable sodium alginate, a pharmaceutically acceptable water swellable polymer, a pharmaceutically acceptable C.sub.2 -C.sub.50 edible hydrocarbon derivative having a melting point ranging from 25.degree. C. and 90.degree. C. and a pharmaceutically acceptable divalent salt selected from the group consisting of an iron salt, a zinc salt, a magnesium salt, an aluminum salt and a calcium salt and mixtures of any of the foregoing and a therapeutically active agent to be administered and a lubricant or lubricants suitable for forming the composition into tablets or capsules and methods of making and using the same.
Claims26
A controlled release pharmaceutical composition for oral administration in humans or animals, comprising
- a controlled release matrix comprising from about 10 to about 80% of the composition by weight of a pharmaceutically acceptable sodium alginate, from about 3 to about 25% of the composition by weight of a pharmaceutically acceptable water swellable polymer, from about 5 to about 45% of the composition by weight a pharmaceutically acceptable C.sub.2 -C.sub.50 edible hydrocarbon derivative having a melting point ranging from 25.degree. C. to 90.degree. C. and a pharmaceutically acceptable divalent salt sufficient to cross-link with the alginate and selected from the group consisting of an iron salt, a zinc salt, a magnesium salt, an aluminum salt and a calcium salt and mixtures of any of the foregoing, with
- a therapeutically effective amount of the active agent to be administered.
A controlled release pharmaceutical composition for oral administration in humans or animals, comprising
- a controlled release matrix comprising a pharmaceutically acceptable sodium alginate in an amount from about 10 to about 80% of said composition by weight, a pharmaceutically acceptable hydroxylalkylcellulose in an amount from about 3 to about 25% of said composition by weight, a pharmaceutically acceptable higher aliphatic alcohol containing from 2 to 50 carbon atoms in an amount from about 5 to about 45% of said composition by weight, and a pharmaceutically acceptable calcium salt in an amount from about 2 to about 12% by weight of the sodium alginate in said composition and,
- a therapeutically effective amount of the active agent to be administered.
A process for producing a controlled release composition for oral administration comprising
- mixing a therapeutically effective amount of an active ingredient to be administered into a controlled release matrix comprising a pharmaceutically acceptable hydroxyethylcellulose in an amount of about 3 to about 25% of said composition by weight, a pharmaceutically acceptable sodium alginate in an amount from about 10 to about 80% of said composition by weight, lactose and a pharmaceutically acceptable calcium salt in an amount from about 2 to about 12% by weight of the composition to form a uniform mixture,
- hydrating the uniform mixture with water to form granules, drying the granules and coating the granules with said higher aliphatic alcohol.
Dependencies are inferred from the claim text.