Antibodies to HER4, human receptor tyrosine kinase
AssigneeBristol-Myers Squibb Company
InventorsGregory D. Plowman, Jean-Michel Culouscou, Mohammed Shoyab, Clay B. Siegall, Ingegerd Hellstrom, Karl E. Hellstrom
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Abstract
The molecular cloning, expression, and biological characteristics of a novel receptor tyrosine kinase related to the epidermal growth factor receptor, termed HER4/p180.sup.erbB4, are described. Antibodies to HER4 are disclosed. A HER4 ligand capable of inducing cellular differentiation of breast cancer cells is also disclosed. In view of the expression of HER4 in several human cancers and in certain tissues of neuronal and muscular origin, various diagnostic and therapeutic uses of HER4-derived and HER4-related biological compositions are provided.
Claims17
An antibody which specifically binds to human HER4, but does not bind to HER2 or HER3.
An antibody which specifically binds to human HER4 expressed in CHO/HER4 21-2 cells as deposited with the American Type Culture Collection and assigned accession number CRL 11205, wherein the antibody does not bind to HER2 or HER3.
A monoclonal antibody which specifically binds the epitope recognized by the monoclonal antibody produced by hybridoma cell line 6-4-11 as deposited with the American Type Culture Collection and assigned accession number HB11715.
A monoclonal antibody which specifically binds the epitope recognized by the monoclonal antibody produced by hybridoma cell line 7-142 as deposited with the American Type Culture Collection and assigned accession number HB11716.
Hybridoma cell line 6-4-11 as deposited with the ATCC and assigned accession number HB11715.
Hybridoma cell line 7-142 as deposited with the ATCC and assigned accession number HB11716.
Dependencies are inferred from the claim text.