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US 5,811,097 AGranted
Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
AssigneeThe Regents of the University of California
InventorsJames Patrick Allison, Dana R. Leach, Matthew F. Krummel
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Abstract
T cell activation in response to antigen is increased by the administration of binding agents that block CTLA-4 signaling. When CTLA-4 signaling is thus blocked, the T cell response to antigen is released from inhibition. Such an enhanced response is useful for the treatment of tumors, chronic viral infections, and as an adjuvant during immunization.
Claims11
A method of decreasing the growth of non-T cell tumor cells in a host, the method comprising:
- administering to said host an effective dose of a CTLA-4 blocking agent, wherein said blocking agent is capable of specifically binding to the extracellular domain of CTLA-4 and inhibiting CTLA-4 signaling;
- wherein said dose is effective to decrease the growth of said tumor cells.
A method of decreasing the growth of carcinoma cells in a host, the method comprising:
- administering intravenously to said host an effective dose of a CTLA-4 blocking agent, wherein said blocking agent is an antibody capable of specifically binding to the extracellular domain of CTLA-4 and inhibiting CTLA-4 signaling;
- wherein said dose is effective to decrease the growth of said carcinoma cells.
Dependencies are inferred from the claim text.