Connective tissue regeneration using human mesenchymal stem cell preparations
AssigneeOsiris Therapeutics, Inc.
InventorsArnold I. Caplan, Stephen E. Haynesworth
Life of this patent
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Abstract
Isolated human mesenchymal stem cells, a method for isolating, purifying, and culturally expanding human mesenchymal stem cells (i.e. mesenchymal stem cells or "MSCs"), and characterization of (including by cytokine expression profiling) and uses, particularly research reagent, diagnostic and therapeutic uses for such cells. The stem cells can be culture expanded without differentiating. Monoclonal antibodies specific for human mesenchymal stem cells and the monoclonal hybridoma cell lines (ATCC nos. 10743-10745) that synthesize and secrete these monospecific antibodies, and uses of the monoclonal antibodies for diagnostic and/or therapeutic purposes.
Claims27
A method of producing a connective tissue which comprises producing connective tissue in an individual in need thereof by administering to said individual a cell preparation containing human mesenchymal stem cells which is recovered from human bone marrow and which is substantially free of blood cells.
A method for producing a connective tissue comprising producing connective tissue in an individual in need thereof by administering to said individual an isolated cell preparation which has been enriched in human mesenchymal stem cells.
A method for enhancing the implantation of a prosthetic device in connective tissue comprising the step of implanting a prosthetic device having human mesenchymal stem cells adhered thereto under conditions suitable for differentiating the cells into connective tissue.
Dependencies are inferred from the claim text.