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OwnerPritish Kumar Chowdhury, Manobjyoti Bordoloi +7inventors
InventorsPritish Kumar Chowdhury, Manobjyoti Bordoloi, Nabin Chandra Baraua, Heramba Prasad Sarmah, Pradip Kumar Goswami, Ram Prakash Saharma, Ajoy Pratap Baruah, Raj Kumar Mathur, Anil Chandra Ghosh
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The invention relates to a process for producing 16-Dehydropregnenolone acetate (16DPA) of the formula shown below ##STR1## which process comprises a) acetolysis of diosgenin of the formula shown below ##STR2## by heating in a pressure reactor in the presence of an acetylating agent and a non-polar solvent, maintaining the pressure in the reactor in the range of 4-6 kg/cm.sup.2 and at a temperature in the range of 200.degree.-250.degree. C. to produce pseudodiosgenine acetate of the formula shown below ##STR3## b) Oxidizing the so obtained pseudodiosgenin acetate to obtain diosone of the formula shown below ##STR4## and, c) Hydrolysis and degradation of the diosone so obtained to produce the said 16-Dehydropregnenolone acetate.
A process for the production of 16-Dehydropregnenolone acetate (16DPA) resented by the formula structure I:
The process in accordance with 1, wherein said oxidation of said pseudodiosgenin acetate is effected in the presence of an oxidizing agent selected from the group consisting of chromium trioxide, pyridinium chlorochromate, pyridinium dichromate, alkali dichromate, potassium permanganate, hydrogen peroxide and mixtures thereof.
The process in accordance with 1, wherein said oxidation of said pseudodiosgenin acetate is effected by applying ultrasound in the presence of an oxidizing agent.
A process for the production of 16-Dehydropregnenolone acetate (16DPA) represented by the formula structure I:
Dependencies are inferred from the claim text.