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US 5,798,368 AGranted
Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNF.alpha. levels
AssigneeCelgene Corporation
InventorsGeorge W. Muller, David I. Stirling, Roger Shen-Chu Chen
Life of this patent
Estimating the term…
Abstract
Tetrasubstituted 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines reduce the levels of TNF.alpha. in a mammal. A typical embodiment is 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4,5,6,7-tetrafluoroisoindoline.
Claims8
A compound of the formula:
- ##STR6## in which each of R.sup.1, R.sup.2, R.sup.3, and R.sup.4, independently of the others, is halo, alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms.
Dependencies are inferred from the claim text.