Inhibitors of rotamase enzyme activity
AssigneesGPI NIL Holdings, Inc., The Johns Hopkins University School of Medicine
InventorsJoseph P. Steiner, Solomon Snyder, Gregory S. Hamilton, Ted Dawson
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Abstract
This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.
Claims34
A method of treating a neurological disorder in an animal, comprising:
- administering to an animal an effective amount of a non-immunosuppressive pipecolic acid derivative having an affinity for FKBP-type immunophilins to stimulate growth of damaged peripheral nerves or to promote neuronal regeneration, wherein the FKBP-type immunophilin exhibits rotamase activity and the non-immunosuppressive pipecolic acid derivative inhibits said rotamase activity of the immunophilin.
A method of treating a neurological disorder in an animal, comprising:
- administering to an animal an effective amount of a non-immunosuppressive pipecolic acid derivative having an affinity for FKBP-type immunophilins in combination with an effective amount of a neurotrophic factor selected from the group consisting of neurotrophic growth factor, brain derived growth factor, glial derived growth factor, cilial neurotrophic factor, and neurotropin-3, to stimulate growth of damaged peripheral nerves or to promote neuronal regeneration, wherein the FKBP-type immunophilin exhibits rotamase activity and the non-immunosuppressive pipecolic acid derivative inhibits said rotamase activity of the immunophilin.
A method of stimulating growth of damaged peripheral nerves, comprising;
- administering to damaged peripheral nerves an effective amount of a non-immunosuppressive pipecolic acid derivative compound having an affinity for FKBP-type immunophilins to stimulate or promote growth of the damaged peripheral nerves, wherein the FKBP-type immunophilins exhibit rotamase activity and the non-immunosuppressive pipecolic acid derivative inhibits said rotamase activity of the immunophilin.
A method for promoting neuronal regeneration and growth in animals, comprising:
- administering to an animal an effective amount of a non-immunosuppressive pipecolic acid derivative compound having an affinity for FKBP-type immunophilins to promote neuronal regeneration, wherein the FKBP-type immunophilins exhibit rotamase activity and the non-immunosuppressive pipecolic acid derivative inhibits said rotamase activity of the immunophilin.
Dependencies are inferred from the claim text.