Use of green porphyrins to treat neovasculature in the eye
AssigneesThe General Hospital Corporation, Quadra Logic Technologies, Inc., Massachuesetts Eye & Ear Infirmary
InventorsJulia Levy, Joan W. Miller, Evangelos S. Gradoudas, Tayyaba Hasan, Ursula Schmidt-Erfurth
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Abstract
Photodynamic therapy of conditions of the eye characterized by unwanted neovasculature, such as age-related macular degeneration, is effective using green porphyrins as photoactive agents, preferably as liposomal compositions.
Claims20
A method to treat conditions of the eye characterized by unwanted neovasculature, which method comprises:
- administering to a primate subject in need of such treatment an amount of liposomal formulation of green porphyrin sufficient to permit an effective amount to localize in said neovasculature;
- permitting sufficient time to elapse to allow an effective amount of said green porphyrin to localize in said neovasculature;
- and
- irradiating the neovasculature with light from a laser, said light being absorbed by the green porphyrin so as to occlude said neovasculature.
A method to treat unwanted choroidal neovasculature which method comprises
- administering to a primate subject in need of such in need of such treatment an amount of green porphyrin sufficient to permit an effective amount to localize in said choroidal neovasculature;
- permitting sufficient time to elapse to allow an effective amount of said green porphyrin to localize in said choroidal neovasculature;
- and
- irradiating said choroidal neovasculature with light from a laser, said light being absorbed by the green porphyrin so as to occlude said neovasculature.
A method to treat age-related macular degeneration (AMD) which method comprises
- administering to a primate subject in need of such treatment an amount of green porphyrin sufficient to permit an effective amount to localize in the choroid;
- permitting sufficient time to elapse to allow an effective amount of said green porphyrin to localize in said choroid;
- and
- irradiating said choroid with light from a laser, said light being absorbed by the green porphyrin.
Dependencies are inferred from the claim text.