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US 5,798,344 AGranted
Phosphonic ester derivatives of quinazolinones
AssigneeOtsuka Pharmaceutical Factory, Inc.
InventorsYasuhisa Kuroki, Kazuyoshi Miyata, Yoshihiko Tsuda, Yasuhide Inoue, Jun Kanaya, Keigo Sato
Life of this patent
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Abstract
The invention provides a phosphonic diester derivative of the formula: ##STR1## wherein R.sup.1 -R.sup.7 are substituent groups, as defined in the specification. The derivatives according to the invention are useful as therapeutic or preventive compositions for hyperlipidemia, hypertension, and diabetes.
Claims17
A phosphonic ester derivative of the formula:
- ##STR28## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.6 are the same or different and each represents a hydrogen atom, a lower alkyl group, a halogen atom, a nitro group, a lower alkoxy group, a cyano group, a phenylsulfonylamino group, a benzoylamino group, an amino group or a halogen-substituted lower alkyl group, R.sup.4 represents a phenyl group, a lower alkyl group, a phenyl(lower)alkyl group optionally substituted by halogen on the phenyl ring, a lower alkenyl group, a carboxy(lower)alkyl group, a (lower)alkoxycarbonyl(lower)alkyl group, a (lower)alkoxy(lower)alkyl group, a lower alkynyl group, a benzoyl(lower)alkyl group, an amino group, a di(lower)alkanoylamino group, a benzylideneamino group optionally having lower alkoxy on the phenyl ring or a pyridylmethylideneamino group, R.sup.5 represents a lower alkyl group, R.sup.7 represents a lower alkoxy group, a hydroxyl group, a phenyl group, a phenyl(lower)alkoxy group optionally having halogen on the phenyl ring or a phenyl(lower)alkylamino group, X.sup.1 and X.sup.2 independently represent an oxygen atom or a sulfur atom, A represents an oxygen atom or a single bond, and Z represents a lower alkylene group.
A phosphonic ester derivative of the formula:
- ##STR29## wherein R.sup.1' represents a hydrogen atom or a halogen atom, R.sup.2' represents a hydrogen atom, a lower alkyl group, a halogen atom, a nitro group or a lower alkoxy group, R.sup.3' represents a hydrogen atom, a halogen atom, a nitro group, a halogen-substituted lower alkyl group, a cyano group, a phenylsulfonylamino group, a benzoylamino group, an amino group or a lower alkoxy group, R.sup.4' represents a phenyl group, a lower alkyl group, a phenyl(lower)alkyl group optionally substituted by halogen on the phenyl ring, a lower alkenyl group, a carboxy(lower)alkyl group, a (lower)alkoxy-carbonyl(lower)alkyl group, a (lower)alkoxy(lower)alkyl group, a lower alkynyl group, a benzoyl(lower)alkyl group, an amino group, a di(lower)alkanoylamino group, a benzylideneamino group optionally having lower alkoxy on the phenyl ring or a pyridylmethylideneamino group, R.sup.5' represents a lower alkyl group, R.sup.6' represents a hydrogen atom, a lower alkoxy group or a halogen atom, R.sup.7' represents a lower alkoxy group, a hydroxyl group, a phenyl group, a phenyl(lower)alkoxy group optionally having halogen on the phenyl ring or a phenyl(lower)alkylamino group, X.sup.1' and X.sup.2' independently represent an oxygen atom or a sulfur atom, A' represents an oxygen atom or a single bond, Z' represents an ethylene group when A' represents an oxygen atom, and Z' represents a methylene group when A' represents a single bond.
Dependencies are inferred from the claim text.