Method of inactivation of viral and bacterial blood contaminants with quinolines as photosensitizer
AssigneeBaxter International Inc.
InventorsRaymond P. Goodrich, Jr., Sang Chul Park
Life of this patent
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Abstract
Viral and bacterial contaminants present in biological solutions are inactivated by mixing one of a novel class of photosensitizer with said solution and irradiating the mixture. Quinoline and quinolone compounds are useful as photosensitizers in this method. With certain photosensitizers a blocking agent may also be employed.
Claims4
A method of inactivating viral, bacterial and parasitic contamination from a composition comprising at least one component selected from the group consisting of blood, a blood component, a cell culture, and a component of a cell culture, comprising the steps of:
- a) mixing said composition with a photosensitizer, wherein said photosensitizer inactivates said viral, bacterial or parasitic contaminant upon absorption of electromagnetic radiation, wherein said photosensitizer is a quinoline having the structure:
- ##STR14## wherein R.sub.1 -R.sub.7 are independently selected from the group consisting of halo, H, linear or branched or substituted alkyl (C.sub.1 -C.sub.15), alkoxy (C.sub.1 -C.sub.15), alkenyl (C.sub.1 -C.sub.15), alkynyl (C.sub.1 -C.sub.15), aryl, amino, thio, thioester, metal and a silicone based substituent;
- and
- b) exposing said composition and said photosensitizer to electromagnetic radiation of sufficient wavelength and intensity for a period of time sufficient to activate said photosensitizer whereby the activation of said photosensitizer reduces said contamination in said composition.
A method of inactivating viral, bacterial and parasitic contamination from a composition comprising at least one component selected from the group consisting of blood, a blood component, a cell culture, and a component of a cell culture, comprising the steps of:
- a) mixing said composition with a photosensitizer, wherein said photosensitizer inactivates said viral, bacterial or parasitic contaminant upon absorption of electromagnetic radiation, wherein said photosensitizer is a quinolone having the structure:
- ##STR16## wherein R.sub.1 -R.sub.6 are independently selected from the group consisting of halo, H, linear or branched or substituted alkyl (C.sub.1 -C.sub.15), alkoxy (C.sub.1 -C.sub.15), alkenyl (C.sub.1 -C.sub.15), aryl, amino, thio, thioester, metal and a silicone based substituent;
- and
- exposing said composition and said photosensitizer to electromagnetic radiation of sufficient wavelength and intensity for a period of time sufficient to activate said photosensitizer whereby the activation of said photosensitizer reduces said contamination in said composition.
Dependencies are inferred from the claim text.