Gastin and CCK receptor ligands

A compound of the formula ##STR22## wherein A represents indole or benzimidazole , wherein W and X replace hydrogen on adjacent carbon atoms,

• m is from 0 to 6, provided that m is not more than 2 unless R.sup.1 is exclusively halo,
• each R.sup.1 is independently selected from the group consisting of halo, amino, amidino, nitro, cyano, hydroxy, sulphamoyl, hydroxysulphonyl, carboxy, esterified carboxy, amidated carboxy, tetrazolyl, C.sub.1 to C.sub.8 alkyl, aryl, substituted aryl, C.sub.1 to C.sub.6 hydroxyalkyl, C.sub.1 to C.sub.6 haloalkyl, C.sub.1 to C.sub.6 alkoxy, C.sub.1 to C.sub.6 alkylcarboxyamino, HON.dbd.C--, R.sup.27 --SO.sub.2 --NH--, R.sup.27 --SO.sub.2 --NH--CO--, R.sup.27 --CO--, R.sup.27 --CO--NH--, R.sup.27 --CO--NH--SO.sub.2 --, R.sup.27 --CO--NH--SO-- and R.sup.28 --NH--SO.sub.2 --,
• wherein R.sup.27 is H, C.sub.1 to C.sub.6 alkyl, C.sub.1 to C.sub.6 haloalkyl, aryl or substituted aryl, and R.sup.28 is H, C.sub.1 to C.sub.6 alkyl, C.sub.1 to C.sub.6 haloalkyl, aryl, substituted aryl, --OH or --CN except that R.sup.27 cannot be H when attached to a sulphur atom,
• W is a carbonyl, sulphonyl or sulphinyl group, and
• X is a carbonyl, sulphonyl or sulphinyl group, provided that at least one of W and X contains carbonyl,
• Y is R.sup.3 --N(R.sup.4)-- or R.sup.3' --O--, wherein R.sup.3 is H or C.sub.1 to C.sub.15 hydrocarbyl, optionally substituted by halogen, wherein up to two CH groups of the hydrocarbyl moiety optionally may be replaced by a nitrogen atom, and wherein up to two CH.sub.2 groups of the hydrocarbyl moiety optionally may be replaced by an oxygen or sulphur atom, R.sup.3' is C.sub.6 to C.sub.15 hydrocarbyl, optionally substituted by halogen, wherein up to two carbon atoms of the hydrocarbyl moiety optionally may be replaced by a nitrogen oxygen or sulphur atom, and
• R.sup.4 is H, C.sub.1 to C.sub.3 alkyl, carboxymethyl or esterified carboxymethyl, provided that Y does not contain a --O--O-- group, and Z is selected from
• i) --O--R.sup.5
• wherein R.sup.5 is H, C.sub.1 to C.sub.5 alkyl, phenyl, substituted phenyl, benzyl or substituted benzyl;
• ii) --N(Q)--H
• wherein Q is H, C.sub.1 to C.sub.5 hydrocarbyl, or R.sup.6 --U, wherein R.sup.6 is a bond or C.sub.1 to C.sub.5 alkylene and U is aryl, substituted aryl, heterocyclic, substituted heterocyclic or cycloalkyl,
• (iii) ##STR23## wherein a is 0 or 1 and b is from 0 to 3, R.sup.7 is H or methyl,
• R.sup.8 is H or methyl;
• or R.sup.8 is CH.sub.2 .dbd. and Q' is absent;
• or R.sup.7 and R.sup.8 are linked to form a 3- to 7-membered ring,
• R.sup.9 is a bond or C.sub.1 to C.sub.5 hydrocarbylene,
• G is a bond, --CHOH-- or --C(0)--
• Q' is as recited above for Q or Q' is R.sup.6 --(C(0)).sub.d --L--(C(0)).sub.e --R.sup.5, wherein R.sup.5 and R.sup.6 are as defined above, L is 0, S or --N(R.sup.10)--, wherein R.sup.10 is as defined above for R.sup.4, and d and e are 0 or 1, provided that d+e<2);
• or Q' and R.sup.8, together with the carbon atom to which they are attached, form a 3- to 7-membered ring,
• Q is as defined above;
• or Q and R.sup.8 together form a group of the formula --(CH.sub.2).sub.f --V--(CH.sub.2).sub.g wherein V is --S--, --S(0)--, S(0).sub.2 --, --CH.sub.2 --, --CHOH-- or --C(0)--, f is from 0 to 2 and g is from 0 to 3;
• or, when Q' is --R.sup.6 --U and U is an aromatic group, Q may additionally represent a methylene link to U, which link is ortho to the R.sup.6 link to U,
• T is H, cyano, C.sub.1 to C.sub.4 alkyl, --CH.sub.2 OH, carboxy, esterified carboxy, amidated carboxy or tetrazolyl;
• and
• iv) ##STR24## wherein R.sup.5 and R.sup.1 are as defined above, R.sup.11 is as defined above for R.sup.4, and R.sup.12 and R.sup.13 are independently a bond or C.sub.1 to C.sub.3 alkylene, provided that R.sup.12 and R.sup.13 together provide from 2 to 4 carbon atoms in the ring,
• wherein said heterocyclic groups are selected from the group consisting of benzimidazolyl, thienyl, furanyl, pyrrolyl, imidazolyl, pyrazolyl, thiazolyl, isothiazolyl, oxazolyl, pyrrolidinyl, pyrrolinyl, imidazolidinyl, imidazolinyl, pyrazolidinyl, tetrahydrofuranyl, pyranyl, pyronyl, pyridyl, pyrazinyl, pyridazinyl, piperidyl, piperazinyl, morpholinyl, thionaphthyl, benzafuranyl, isobenzofuryl, indolyl, oxyindolyl, isoindolyl, indazolyl, indolinyl, 7-azaindolyl, isoindazolyl, benzopyranyl, coumarinyl, isocoumarinyl, quinolyl, isoquinolyl, naphthridinyl, cinnolinyl, quinazolinyl, pyridopyridyl, benzoxazinyl, quinoxadinyl, chromenyl, chromanyl, isochromanyl and carbolinyl,
• and wherein said substituted aryl, benzyl, phenyl, or heterocyclic groups independently are substituted with up to 3 substituents, independently selected from the group consisting of halo, amino, amidino, nitro, cyano, hydroxy, sulphamoyl, hydroxysulphonyl, carboxy, esterified carboxy, amidated carboxy, tetrazolyl, C.sub.1 to C.sub.8 alkyl, C.sub.1 to C.sub.6 hydroxyalkyl, C.sub.1 to C.sub.6 haloalkyl, C.sub.1 to C.sub.6 alkoxy, C.sub.1 to C.sub.6 alkylcarboxyamino, HON.dbd.C--, R.sup.27 --SO.sub.2 --NH--, R.sup.27 --SO.sub.2 --NH--CO--, R.sup.27 --CO--, R.sup.27 --CO--NH--, R.sup.27 --CO--NH--SO.sub.2 --, R.sup.27 --CO--NH--SO-- and R.sup.28 --NH--SO.sub.2 --,
• or a pharmaceutically acceptable salt thereof.