Androgens and anabolic agents
AssigneeJenapharm GmbH & Co. KG
InventorsRolf-Dieter Hesch, Michael Oettel, Peter Droescher, Sigfrid Schwarz, Bernd Menzenbach, Wolfgang Romer, Gunter Kaufmann, Jens Schroder
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AssigneeJenapharm GmbH & Co. KG
InventorsRolf-Dieter Hesch, Michael Oettel, Peter Droescher, Sigfrid Schwarz, Bernd Menzenbach, Wolfgang Romer, Gunter Kaufmann, Jens Schroder
Estimating the term…
Novel androgens having one or more substituents providing radical trapping properties are disclosed as useful in methods of treating androgen deficiency in man, benign prostate hypotropy and carcinoma of the prostate, osteoporosis, vascular disease-induced or ischemically-induced cerebral edemas, subarachnoid hemorrhages, ischemic shock, cerebral insult, Parkinson's disease and Alzheimer's disease. The androgen compound used for treating androgen deficiency in man has a steroid ring with an .alpha.-tocopherol group or a trolox group substituent.
A compound selected from the group consisting of androgens having at least one substituent providing radical trapping properties, wherein said at least one substituent is selected from the group consisting of an .alpha.-tocopherol group and a trolox group.
A method of treating androgen deficiency comprising administering an effective amount of an androgen having at least one substituent providing radical trapping properties to a man suffering from androgen deficiency, wherein said at least one substituent is selected from the group consisting of an .alpha.-tocopherol group and a trolox group.
A method of treating prostate hypotrophy and prostate carcinoma, said method comprising administering an effective amount of an androgen having at least one substituent providing radical trapping properties to a man suffering from said prostate hypotrophy and prostate carcinoma, wherein said at least one substituent is selected from the group consisting of an .alpha.-tocopherol group and a trolox group.
A method of treating osteoporosis, said method comprising administering an effective amount of an androgen having at least one substituent providing radical trapping properties to an individual suffering from said osteoporosis, wherein said at least one substituent is selected from the group consisting of an .alpha.-tocopherol group and a trolox group.
A method of treating vascular disease-induced or ischemically-induced cerebral edemas, subarachnoid hemorrhages, ischemic shock and cerebral insult, said method comprising administering an effective amount of an androgen having at least one substituent providing radical trapping properties to an individual, wherein said at least one substituent is selected from the group consisting of an .alpha.-tocopherol group and a trolox group.
A method of treating asthma, said method comprising administering an effective amount of an androgen having at least one substituent providing radical trapping properties to an individual suffering from said asthma, wherein said at least one substituent is selected from the group consisting of an .alpha.-tocopherol group and a trolox group.
A method of treating Alzheimer's disease, said method comprising administering an effective amount of an androgen having at least one substituent providing radical trapping properties to an individual suffering from said Alzheimer's disease, wherein said at least one substituent is selected from the group consisting of an .alpha.-tocopherol group and a trolox group.
A method of treating Parkinson's disease, said method comprising administering an effective amount of an androgen having at least one substituent providing radical trapping properties to an individual suffering from said Parkinson's disease, wherein said at least one substituent is selected from the group consisting of an .alpha.-tocopherol group and trolox group.
A method of preventing rejection of an organ transplanted during an organ transplantation procedure, said method comprising administering an effective amount of an androgen having at least one substituent providing radical trapping properties to an individual having said transplantation procedure, wherein said at least one substituent is selected from the group consisting of an .alpha.-tocopherol group and a trolox group.
A method of treating androgen-dependent malignant neoplasms, said method comprising administering an effective amount of an androgen having at least one substituent providing radical trapping properties to an individual having said androgen-dependent malignant neoplasms, wherein said at least one substituent is selected from the group consisting of an .alpha.-tocopherol group and a trolox group.
Dependencies are inferred from the claim text.