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US 5,795,594 AGranted
Salmeterol xinafoate with controlled particle size
AssigneeGlaxo Group Limited
InventorsPeter York, Mazen Hanna
Life of this patent
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Abstract
The present invention relates to particulate products which may be prepared by methods and apparatus using supercritical fluids. More particularly, the invention relates to pharmaceutical products, in particular easily handled and easily fluidized crystalline forms of salmeterol xinafoate, with controlled particle size and shape.
Claims15
4-Hydroxy-.alpha..sup.1 -6-(4-phenylbutoxy)hexyl!amino!methyl!-1,3-benzenedimethanol (salmeterol), 1-hydroxy-2-naphthalenecarboxylate (xinafoate) in an easily fluidized crystalline form, with a dynamic bulk density of less than 0.1 g.cm.sup.-3.
Dependencies are inferred from the claim text.