Adjuvant properties of poly (amidoamine) dendrimers
AssigneeNovavax, Inc.
InventorD. Craig Wright
Life of this patent
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Abstract
A new method of adjuvanting a variety of materials has been developed. Starburst dendrimers, primarily poly(amidoamine) starburst dendrimers, can be used as an adjuvant for Influenza antigen and similar materials. Mid-Generation dendrimers are preferred and yield high antibody titer levels with reduced antigen dosage.
Claims16
A vaccine for Influenza comprising an effective amount of a composition formed of an Influenza antigen and a starburst dendrimer in a physiologically compatible carrier;
- the amount of said Influenza antigen in said composition being substantially reduced from the amount necessary to yield a comparable antigenic response if given without said dendrimer.
A method of preparing a vaccine for protection against Influenza which requires a lower level of antigen than conventional Influenza vaccines, the method comprising the steps of mixing an Influenza antigen with a starburst dendrimer, and diluting the mixture with a physiologically compatible carrier until said vaccine is prepared.
Dependencies are inferred from the claim text.