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AssigneeThe Regents of the University of California
InventorsBob B. Buchanan, Karoly Kobrehel, Boihon C. Yee, Rosa Lozano, Oscar L. Frick, Richard W. Ermel
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Thioredoxin, a small dithiol protein, is a specific reductant for major allergenic proteins present in widely used foods from animal and plant sources. All targeted allergenic proteins contain disulfide (S--S) bonds that are reduced to the sulfhydryl (SH) level by thioredoxin. The proteins are allergenically active in the oxidized (S--S) state. When reduced (SH state), they lose their allergenicity. Thioredoxin achieved this reduction when activated (reduced) either by NADPH via NADP-thioredoxin reductase (physiological conditions) or by dithiothreitol, a chemical reductant. Skin tests and feeding experiments carried out with sensitized dogs showed that treatment of the food with reduced thioredoxin prior to ingestion eliminated or decreased the allergenicity of the food.
An ingestible food product containing added thioredoxin and nicotinamide adenine dinucleotide phosphate-thioredoxin reductase (NTR) and further containing nicotinamide adenine dinucleotide phosphate (NADP) that resulted from added reduced nicotinamide adenine dinucleotide phosphate (NADPH).
A hypo-allergenic, ingestible food product that has been treated with thioredoxin, nicotinamide adenine dinucleotide phosphate-thioredoxin reductase (NTR) and reduced nicotinamide adenine dinucleotide phosphate (NADPH).
An ingestible meat food product containing added thioredoxin and nicotinamide adenine dinucleotide phosphate-thioredoxin reductase (NTR) and further containing nicotinamide adenine dinucleotide phosphate (NADP) that resulted from added reduced nicotinamide adenine dinucleotide phosphate (NADPH).
A hypo-allergenic, ingestible food product containing meat that has been treated with thioredoxin, nicotinamide adenine dinucleotide phosphate-thioredoxin reductase (NTR) and reduced nicotinamide adenine dinucleotide phosphate (NADPH).
An ingestible milk food product containing added thioredoxin and nicotinamide adenine dinucleotide phosphate-thioredoxin reductase (NTR) and further containing nicotinamide adenine dinucleotide phosphate (NADP) that resulted from added reduced nicotinamide adenine dinucleotide phosphate (NADPH).
A hypo-allergenic, ingestible food product containing milk that has been treated with thioredoxin, nicotinamide adenine dinucleotide phosphate-thioredoxin reductase (NTR) and reduced nicotinamide adenine dinucleotide phosphate (NADPH).
An ingestible egg food product containing added thioredoxin and nicotinamide adenine dinucleotide phosphate-thioredoxin reductase (NTR) and further containing nicotinamide adenine dinucleotide phosphate (NADP) that resulted from added reduced nicotinamide adenine dinucleotide phosphate (NADPH).
A hypo-allergenic, ingestible food product containing egg that has been treated with thioredoxin, nicotinamide adenine dinucleotide phosphate-thioredoxin reductase (NTR) and reduced nicotinamide adenine dinucleotide phosphate (NADPH).
An ingestible soy food product containing added thioredoxin and nicotinamide adenine dinucleotide phosphate-thioredoxin reductase (NTR) and further containing nicotinamide adenine dinucleotide phosphate (NADP) that resulted from added reduced nicotinamide adenine dinucleotide phosphate (NADPH).
A hypo-allergenic, ingestible food product containing soy that has been treated with thioredoxin, nicotinamide adenine dinucleotide phosphate-thioredoxin reductase (NTR) and reduced nicotinamide adenine dinucleotide phosphate (NADPH).
An ingestible wheat food product containing added thioredoxin and nicotinamide adenine dinucleotide phosphate-thioredoxin reductase (NTR) and further containing nicotinamide adenine dinucleotide phosphate (NADP) that resulted from added reduced nicotinamide adenine dinucleotide phosphate (NADPH).
A hypo-allergenic, ingestible food product containing wheat that has been treated with thioredoxin, nicotinamide adenine dinucleotide phosphate-thioredoxin reductase (NTR) and reduced nicotinamide adenine dinucleotide phosphate (NADPH).
An ingestible rice food product containing added thioredoxin and nicotinamide adenine dinucleotide phosphate-thioredoxin reductase (NTR) and further containing nicotinamide adenine dinucleotide phosphate (NADP) that resulted from added reduced nicotinamide adenine dinucleotide phosphate (NADPH).
A hypo-allergenic, ingestible food product containing rice that has been treated with thioredoxin, nicotinamide adenine dinucleotide phosphate-thioredoxin reductase (NTR) and reduced nicotinamide adenine dinucleotide phosphate (NADPH).
Dependencies are inferred from the claim text.