Multi-reactor synthesizer and method for combinatorial chemistry
AssigneeSmithKline Beecham Corporation
InventorsMichael L. Moore, Dennis Yamashita
Life of this patent
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Abstract
Solid phase combinatorial synthesis is carried out in a multi-reactor synthesizer comprising an array of separate reactor cells containing a solid reaction support medium. Subsets of reactor cells are interconnected with one another in a desired pattern, and, in a first reaction step, reagents are circulated through the subsets. After the first reaction step is completed, the reactor cells are rearranged into a new configuration of subsets, and the same, or other, reagents are circulated through the new subsets. The process can be repeated to produce large numbers of compounds differing from one another.
Claims5
A multi-reactor synthesizer for combinatorial chemistry comprising:
- a set of reactor cells, each reactor cell having an inlet and an outlet;
- pumping means for producing separate flow of plural reagents;
- and
- means for interconnecting said reactor cells with one another and with said pumping means to establish plural reagent flow paths, with a different reagent in each of said flow paths and with a subset of said reactor cells in each of said flow paths, each subset consisting of a plurality of said reactor cells connected in series;
- in which the reactor cells are connectible to, and disconnectible from, one another so that new plural reagent flow paths can be established through different subsets of said reactor cells, each of said different subsets also consisting of a plurality of said reactor cells connected in series.
Dependencies are inferred from the claim text.