# US 5,790,964 A · Methods of removing radioactively labeled biological molecules from liquid radioactive waste

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- Number: US 5,790,964 A
- Document ID: US5790964A
- Status: Granted
- Kind: A
- Application number: 08/657,748
- Filed: 1996-05-31
- Granted: 1998-08-04
- Earliest claimed: 1993-06-08
- Assignees: Cortex Biochem, Inc.
- Inventors: Matt Pourfarzaneh
- Web page: https://patentgrep.com/patent/US5790964A

## CPC

- G21F 9/12: by absorption; by adsorption; by ion-exchange
- G21F: PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT; TREATING RADIOACTIVELY CONTAMINATED MATERIAL; DECONTAMINATION ARRANGEMENTS THEREFOR (radiation protection by pharmaceutical means A61K8/00, A61Q17/04; in cosmonautic vehicles B64G1/54; combined with a reactor G21C11/00; combined with X-ray tubes H01J35/16; combined with X-ray apparatus H05G1/02)

## Abstract

This invention relates to the processing of liquid radioactive waste containing radioactively labeled biological molecules. More specifically, this invention relates to the use of solid phase binders to remove radioactively labeledbiological molecules from liquid radioactive waste solutions.

## Claims

### Claim 1

A method of removing a radioactively labeled biological molecule from a liquid radioactive waste solution comprising the steps of:
(a) contacting said liquid radioactive waste solution with a solid phase binder consisting of a solid phase adsorbent attached to, or entrapped in, a polymer or resin to form a solid phase binder radioactively labeled biological molecule complex; and
(b) separating said complex from said liquid radioactive waste solution to remove the radioactively labeled biological molecule from the liquid radioactive waste solution.

### Claim 2 (depends on 1)

The method of claim 1 wherein said radioactively labeled biological molecule contains a gamma emitting radioisotope.

### Claim 3 (depends on 2)

The method of claim 2 wherein said radioactively labeled biological molecule is an .sup.125 I-labeled molecule.

### Claim 4 (depends on 3)

The method of claim 3 wherein said .sup.125 I-labeled molecule is .sup.125 I thyroxine.

### Claim 5 (depends on 3)

The method of claim 3 wherein said .sup.125 I-labeled molecule is .sup.125 I folate.

### Claim 6 (depends on 2)

The method of claim 2 wherein said radioactively labeled biological molecule is a .sup.57 Co-labeled molecule.

### Claim 7 (depends on 6)

The method of claim 6 wherein said .sup.57 Co-labeled molecule is .sup.57 Co vitamin B12.

### Claim 8 (depends on 1)

The method of claim 1 wherein more than one radioactively labeled biological molecule is present in the radioactive waste solution.

### Claim 9 (depends on 8)

The method of claim 8 wherein said radioactively labeled biological molecules are .sup.125 I folate and .sup.57 Co vitamin B12.

### Claim 10 (depends on 8)

The method of claim 8 wherein more than one solid phase binder is contacted with said liquid radioactive waste solution to form more than one solid phase binder:radioactively labeled biological molecule complex.

### Claim 11 (depends on 1)

The method of claim 1 wherein said solid phase adsorbent is a charcoal adsorbent.

### Claim 12 (depends on 1)

The method of claim 1 wherein said solid phase binder is in a column, and wherein said liquid radioactive waste solution is passed through the column in order to remove the radioactively labeled biological molecule from the liquid radioactive waste solution.

### Claim 13 (depends on 12)

The method of claim 12 wherein said solid phase binder is also consists of a solid phase immunochemical binder.

### Claim 14 (depends on 13)

The method of claim 13 wherein said solid phase immunochemical binder comprises antibodies attached to glass beads.

### Claim 15 (depends on 1)

The method of claim 1 wherein said polymer or resin is selected from the group consisting of polyacrylamide, polyacrolein, cellulose polymers, and celite.

### Claim 16

A method of removing a radioactively labeled biological molecule from a liquid radioactive waste solution comprising the steps of:
(a) contacting said liquid radioactive waste solution with a solid phase immunochemical binder to form a solid phase immunochemical binder:radioactively labeled biological molecule complex; and
(b) separating said complex from said liquid radioactive waste solution to remove the radioactively labeled biological molecule from the liquid radioactive waste solution.

### Claim 17 (depends on 16)

The method of claim 16 wherein said solid immunochemical binder is an antibody attached to a solid phase.

### Claim 18 (depends on 16)

The method of claim 16 further comprising the step of binding said radioactively labeled biological molecule to a liquid phase antibody, wherein said solid phase immunochemical binder binds to said liquid phase antibody to form the solid phase binder adsorbent:radioactively labeled biological molecule complex of step (a).