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US 5,789,601 AGranted
Method of inactivation of viral and bacterial blood contaminants
AssigneeBaxter International Inc.
InventorsSang Chul Park, Raymond P. Goodrich, Jr., Nagender Yerram, Samuel O. Sowemimo-Coker, Matthew S. Platz, Brian M. Aquila
Life of this patent
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Abstract
Viral and bacterial contaminants present in biological solutions are inactivated by mixing one of a novel class of photosensitizer with said solution and irradiating the mixture.
Claims11
A photosensitizer capable of binding viral, bacterial, or parasitic contaminants in a biological solution, and further capable of inactivating said viral, bacterial or parasitic contaminant upon irradiation without substantially impairing said biological solution, comprised of the formula:
- ##STR12## wherein .mu. is an integer of 1 ;
- X is an anionic counterion;
- Z is N or P;
- R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are independently halo;
- H;
- linear or branched alkyl of 1-10 carbon atoms;
- liner or branched alkoxy of 1-10 carbon atoms;
- (CH.sub.2).sub.m O(CH.sub.2).sub.p Z.sym.R'R"R"' or --O(CH.sub.2).sub.n Z.sym.R'R"R"' wherein n, m and p are independently integers from 1 to 10 and R',R", and R"' are independently H or linear or branched alkyl of 1 to 10 carbon atoms with the proviso that on each Z atom, not more than two of R',R", or R"'may by H;
- and at least on one of R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 or R.sub.6 is --(CH.sub.2).sub.m O(CH.sub.2).sub.p Z.sym.R'R"R"' or --O(CH.sub.2).sub.n Z.sym.R'R"R"'.
6 more elements
Dependencies are inferred from the claim text.