Treatment of urinary incontinence with nitric oxide synthase substrates and/or nitric oxide donors alone or in combination with estrogen or progesterone and/or other agents
AssigneeSchering Corporation
InventorsRobert E. Garfield, Kristof Chwalisz
Life of this patent
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Abstract
The invention provides a method for the treatment and prevention of urinary incontinence in mammals, e.g., human males and females, especially nonpregnant female mammals, by administering a nitric oxide synthase substrate and/or nitric oxide donor, alone or in combination with an estrogenic agent and/or a progestational substance, with or without supplementation with an alpha-adrenergic agonist, beta-adrenergic receptor blocking agent, cholinergic-receptor blocking compound or a cholinergic-receptor-stimulating drug, as well as pharmaceutical compositions useful in practicing the methods of this invention.
Claims21
A method of treating urinary incontinence symptoms in a female mammal, comprising administering to said female an effective amount of
- (a) a nitric oxide synthase substrate, a nitric oxide donor, or both, and, optionally, further administering an effective amount of
- (b) one or more of a progestin, an estrogen or a partial estrogen agonist.
Dependencies are inferred from the claim text.