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US 5,789,162 AGranted
Methods of synthesizing diverse collections of oligomers
AssigneeAffymax Technologies N.V.
InventorsWilliam J. Dower, Ronald W. Barrett, Mark A. Gallop
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Abstract
A general stochastic method for synthesizing random oligomers on particles is disclosed. A further aspect of the invention relates to the use of identification tags on the particles to facilitate identification of the sequence of the monomers in the oligomer.
Claims6
A method of recording each step in a synthesis of a compound, said compound being produced by step-by-step assembly of building blocks, said method comprising the steps of:
- (a) coupling to a solid support a first building block and a first identifier tag under conditions compatible with immobilization of the first building block and the first identifier tag, wherein said first identifier tag identifies the first building block and wherein said first identifier tag is a nucleotide or oligonucleotide;
- (b) repeating step (a) until the desired compound is prepared on said solid support;
- and
- (c) sequencing the identifier tags that are present on said solid support to identify the corresponding building blocks coupled to said solid support.
1 more element
Dependencies are inferred from the claim text.