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AssigneePacific Northwest Cancer Foundation
InventorsGerald P. Murphy, Alton L. Boynton, Benjamin A. Tjoa
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Methods and compositions for use of human dendritic cells to activate T cells for immunotherapeutic responses against primary and metastatic prostate cancer are disclosed. In one embodiment, human dendritic cells, after exposure to a prostate cancer antigen or specific antigenic peptide, are administered to a prostate cancer patient to activate the relevant T cell responses in vivo. In an alternate embodiment, human dendritic cells are exposed to a prostate cancer antigen or specific antigenic peptide in vitro and incubated or cultured with primed or unprimed T cells to activate the relevant T cell responses in vitro. The activated T cells are then administered to a prostate cancer patient. Methods and compositions for human dendritic cells with extended life span and cryopreserved dendritic cells are disclosed.
A method for producing a cancer growth inhibiting response, comprising administering, to a prostate cancer patient in need thereof, an effective amount of human dendritic cells, exposed in vitro to a prostate tissue antigen in which the prostate tissue antigen is selected from the group consisting of a lysate of LNCAP cells, a membrane preparation of LNCAP cells, a lysate of prostate tumor cells of the prostate cancer patient, a membrane preparation of prostate tumor cells of the prostate cancer patient, purified prostate specific membrane antigen (PSMA), a peptide having the amino acid sequence LLHETDSAV, a peptide having the amino acid sequence LHBETDSAV, and a peptide having the amino acid sequence LXXXXXXV where X represents any amino acid.
Dependencies are inferred from the claim text.