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US 5,788,960 AGranted
Technetium-99M labeled polypeptides for imaging
AssigneeDiatech, Inc.
InventorRichard T. Dean
Life of this patent
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Abstract
The invention relates to radiolabeled imaging of a mammalian body. The invention in particular provides for reagents labeled with technetium-99 m for such imaging. The invention provides peptides which bind technetium-99 m and which can be targeted to specific sites within a mammalian body.
Claims5
A technetium-99 m labeled scintigraphic imaging agent comprising, in combination:
- (a) a peptide of 3 to 100 amino acids that specifically binds to a target site to be imaged;
- and
- (b) a technetium-99 m binding moiety of the formula
- --C(aa)C--
- wherein C is a cysteine amino acid residue and (aa) is any primary .alpha.- or .beta.-amino acid, the technetium-99 m binding moiety being covalently bound to the peptide, wherein the peptide specifically binds to clots, tumors, sites of infection, atherosclerotic plaques, amyloid plaques or bone.
2 more elements
Dependencies are inferred from the claim text.