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US 5,786,462 AGranted
High affinity ssDNA ligands of HIV-1 reverse transcriptase
AssigneeNeXstar Pharmaceuticals, Inc.
InventorsDaniel J. Schneider, Larry Gold, Juli Feigon
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Abstract
Methods are described for the identification and preparation of DNA ligands to the HIV-1 reverse transcriptase protein. Included in the invention are specific ssDNA ligands to HIV-1 reverse transcriptase identified by the SELEX method. Also included are ssDNA ligands that inhibit HIV-1 reverse transcriptase.
Claims1
A purified and isolated non-naturally occurring DNA ligand to HIV-1 reverse transcriptase wherein said ligand is selected from the group consisting of the sequences set forth in SEQ ID NOS:
- 6-72 and 76-94.
Dependencies are inferred from the claim text.