Chemiluminescent acridinium salts
AssigneeAbbott Laboratories
InventorsPhillip Gregory Mattingly, Larry Gene Bennett
Life of this patent
Estimating the term…
Abstract
Acridinium sulfonylamides and isomers, such as phenanthridinium sulfonylamides, may be employed in applications including chemiluminmescent immunoassays. Methods for synthesis of these compounds include contacting an amine with a sulfonylhalide to form a sulfonamide and acylating with an activated carboxylic acid of an acridine or isomer thereof. The N-sulfonyl-9-acridinium carboxamide and isomers may be conjugated to antigens, haptens, antibodies, and nucleic acids for use in chemiluminescent assays.
Claims24
The chemiluminescent compound 10-methyl-N-(2-carboxyethyl)-N-tosyl-9-acridinium carboxamide.
The chemiluminescent compound 10-methyl-N-(4-carboxybutyl)-N-tosyl-9-acridinium carboxamide.
The chemiluminescent compound 10-methyl-N-(5-carboxypentyl)-N-tosyl-9-acridinium carboxamide.
The chemiluminescent compound 10-(3-sulfopropyl)-N-(2-carboxyethyl)-N-tosyl-9-acridinium carboxamide.
The chemiluminescent compound 10-(3-sulfopropyl)-N-(3-sulfopropyl)-N-tosyl-9-acridinium carboxamide.
The chemiluminescent compound 10-methyl-N-(5-carboxypentyl)-N-(p-bromobenzenesulfonyl)-9-acridinium carboxamide.
The chemiluminescent compound 10-methyl-N-(5-carboxypentyl)-N-(p-nitro-benzenesulfonyl)-9-acridinium carboxamide.
The chemiluminescent compound 10-methyl-N-phenyl-N-tosyl-9-acridinium carboxamide.
The chemiluminescent compound 10-methyl-N-phenyl-N-(p-bromobenzenesulfonyl)-9-acridinium carboxamide.
The chemiluminescent compound 10-methyl-N-phenyl-N-(p-nitrobenzenesulfonyl)-9-acridinium carboxamide.
The chemiluminescent compound 10-methyl-N-phenyl-N-(o-nitrobenzenesulfonyl)-9-acridinium carboxamide.
The chemiluminescent compound 10-methyl-N-phenyl-N-trifluoromethanesulfonyl-9-acridinium carboxamide trifluoromethanesulfonate.
The chemiluminescent compound 10-methyl-N-isopropyl-N-tosyl-9-acridinium carboxamide.
The chemiluminescent compound 10-methyl-N-isopropyl-N-(p-bromobenzenesulfonyl)-9-acridinium carboxamide trifluoromethanesulfonate.
The chemiluminescent compound 10-methyl-N-isopropyl-N-(o-nitrobenzenesulfonyl)-9-acridinium carboxamide trifluoromethanesulfonate.
The chemiluminescent compound 10-methyl-N-isopropyl-N-trifluoromethanesulfonyl-9-acridinium carboxamide trifluoromethanesulfonate.
The chemiluminescent compound 10-methyl-N-butyl-N-(2,4,6-trimethylbenzenetriflouromethanesufonate.
The chemiluminescent compound 10-methyl-N-butyl-N-(2,4,6-triisopropylbenzenesulfonyl)-9-acridinium carboxamide triflouromethanesufonate.
The chemiluminescent compound 10-methyl-N-butyl-N-tosyl-9-acridinium carboxamide trifluoromethanesulfonate.
The chemiluminescent compound 10-methyl-N-butyl-N-(p-bromobenzenesulfonyl)-9-acridinium carboxamide trifluoromethanesulfonate.
The chemiluminescent compound 10-methyl-N-butyl-N-(o-nitrophenylsulfonyl)-9-acridinium carboxamide trifluoromethanesulfonate.
The chemiluminescent compound 10-methyl-N-butyl-N-(p-nitrobenzenesulfonyl)-9-acridinium carboxamide trifluoromethanesulfonate.
The chemiluminescent compound 10-methyl-N-butyl-N-(2,4-dinitrobenzenesulfonyl)-9-acridinium carboxamide trifluoromethanesulfonate.
The chemiluminescent compound 10-methyl-N-allyl-N-tosyl-9-acridinium carboxamide trifluoromethanesulfonate.
Dependencies are inferred from the claim text.