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AssigneeThe United States of America as represented by the Secretary of the Department of Health and Human Sevices
InventorsMichael R. Boyd, John H. Cardellina, II, Kirk R. Gustafson, Laurent A. Decosterd, Ian Parson, Lewis Pannell, James B. McMahon, Gordon M. Cragg
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The present invention provides novel antiviral naphthoquinone compounds, which may be isolated from plants of the genus Conospermum or synthesized chemically, in accordance with the present inventive methods. The antiviral naphthoquionone compounds, derivatives thereof, and prodrugs thereof, may be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the growth or replication of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2, in the treatment or prevention of viral infection.
An antiviral naphthoquinone selected from the group consisting of:
A method of treating a retroviral infection, which comprises administering to a host an effective amount of at least one compound selected from the group consisting of an antiviral naphthoquinone, in substantially pure form, selected from the group consisting of:
Dependencies are inferred from the claim text.