Methods for inhibiting rejection of transplanted tissue
AssigneeThe General Hospital Corporation
InventorDenise Faustman
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Abstract
A method for inhibiting rejection by a recipient animal of a transplanted tissue, said method comprising modifying, eliminating, or masking an antigen which, when present on the surface of a cell of said tissue, is capable of causing a T-lymphocyte-mediated response in said animal, to inhibit antigen-mediated interaction between said cell and a T-lymphocyte of said animal without causing lysis of said cell.
Claims19
A porcine sample for xenotransplantation into a human patient, said sample containing cells of a type normally bearing a surface class I antigen capable of causing a T-lymphocyte-mediated response, wherein said class I antigen on cells of said sample is modified, masked, or has been eliminated to decrease said T-lymphocyte-mediated response, without causing lysis of said cells following xenotransplantation into said human patient.
Dependencies are inferred from the claim text.