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US 5,783,208 AGranted
Transdermal drug delivery matrix for coadministering estradiol and another steroid
AssigneeTheratech, Inc.
InventorsSrinivasan Venkateshwaran, Charles D. Ebert
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Abstract
A matrix type transdermal patch for coadministering estradiol and another steroid wherein the matrix is composed of a N-vinyl-2-pyrrolidone-containing acrylic copolymer pressure sensitive adhesive, estradiol, the other steroid, and optionally a permeation enhancer, and the respective fluxes of estradiol and the other steroid from the matrix are independent of the respective concentrations of the other steroid and estradiol in the matrix.
Claims9
A transdermal patch for administering estradiol and another steroid comprising:
- a) a backing layer;
- and
- b) a matrix layer comprising:
- (i) a pressure sensitive adhesive copolymer of N-vinyl-2-pyrrolidone-and 2-ethylhexyl acrylate;
- (ii) estradiol;
- and
- (iii) another sex steroid other than an estradiol or ester of an estradiol, wherein the flux of said sex steroid from the matrix layer is independent of the concentration of estradiol in the matrix layer and the flux of estradiol from the matrix layer is independent of the concentration of the other sex steroid in the matrix layer.
4 more elements
Dependencies are inferred from the claim text.