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US 5,783,179 AGranted
C-reactive protein fragment with immunomodulatory activity
AssigneeSyntex (U.S.A.) Inc.
InventorsJohn J. Nestor, Jr., Teresa H. Ho, Deborah A. Eppstein, Philip L. Felgner, Barbara P. Barna, Sharad D. Deodhar
Life of this patent
Estimating the term…
Abstract
Compounds having immunomodulatory activity comprising the optionally modified dodecapeptide fragment A-(SEQ ID No: 1)-B corresponding to residues 174 to 185 of C-reactive protein (CRP), pharmaceutical compositions thereof, and methods of treating cancer with the compositions. Liposomal formulations containing the CRP-peptide fragment are particularly efficacious when administered in conjunction with interleukin-2.
Claims15
A polypeptide having the amino acid sequence A-(SEQ ID NO:
- 1)-B, A-Ile-Tyr-Leu-Gly-Gly-Pro-Phe-Ser-Pro-Asn-Val-Leu-B, wherein A is H or an acyl group and B is OH or NR.sub.2, each R independently selected from H, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 haloalkyl, and C.sub.1- C.sub.6 aralkyl.
Dependencies are inferred from the claim text.